Diversity-Oriented Approach to Pyrrole-Imidazole Alkaloid Frameworks
نویسندگان
چکیده
منابع مشابه
Synthesis of the Pyrrole-Imidazole Alkaloid Sventrin from the Marine Sponge Agelas sventres
Gregor Breckle, Kurt Polborn, and Thomas Lindel Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstr. 5Ð13, D-81377 Munich, Germany Reprint requests to Prof. Dr. Th. Lindel. Fax int: +(0)89/2180-7-7734. E-mail: [email protected] Z. Naturforsch. 58b, 451Ð456 2003; received February 17, 2003 The marine pyrrole-imidazole alkaloid sventrin (1) and the hither...
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The alkaloid ageladine A, a pyrrole-imidazole alkaloid isolated from marine Agelas sponges shows fluorescence in the blue-green range during excitation with UV light with the highest absorption at 370 nm. The fluorescence of this alkaloid is pH dependent. Highest fluorescence is observed at pH 4, lowest at pH 9 with the largest fluorescence changes between pH 6 and 7. Ageladine A is brominated,...
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Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA damage and inhibition of transcription. We report that a DNA minor groove binding hairpin pyrrole-imidazole (Py-Im) polyamide interferes with RNA polymerase II (RNAP2) activity in cell culture. Polyamide treatment activates p53 signaling in LNCaP prostate cancer cells without detectable DNA damage. Genome-wi...
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In his most celebrated tale "The Picture of Dorian Gray", Oscar Wilde stated that "those who go beneath the surface do so at their peril". This sentence could be a prophetical warning for the practitioner who voluntarily challenges himself with trying to synthesize marine sponge-deriving pyrrole-imidazole alkaloids. This now nearly triple-digit membered community has been growing exponentially ...
متن کاملSolution-phase synthesis of pyrrole-imidazole polyamides.
Pyrrole-imidazole polyamides are DNA-binding molecules that are programmable for a large repertoire of DNA sequences. Typical syntheses of this class of heterocyclic oligomers rely on solid-phase methods. Solid-phase methodologies offer rapid assembly on a micromole scale sufficient for biophysical characterizations and cell culture studies. In order to produce gram-scale quantities necessary f...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2011
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol200067e